Tri-Luma

Pronunciation: floo-oh-SIN-oh-lone/hye-droe-KWIN-one/TREH-tih-noyn
Generic Name: Fluocinolone/Hydroquinone/Tretinoin
Brand Name: Tri-Luma

Tri-Luma is used for:

Short-term treatment of moderate to severe melasma (darkening) of the face. It is used in combination with sun avoidance measures, including sunscreen use. It may also be used for other conditions as determined by your doctor.

Tri-Luma is a combination topical corticosteroid, depigmentation agent, and keratolytic. Exactly how Tri-Luma works to treat melasma is unknown.

Do NOT use Tri-Luma if:

• you are allergic to any ingredient in Tri-Luma

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tri-Luma:

Some medical conditions may interact with Tri-Luma. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have eczema, an abnormally high white blood cell count, a sunburn, or asthma


• if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin


• if you have measles, tuberculosis (TB), chickenpox, or shingles, or you have had a positive TB test or a recent vaccination

Some MEDICINES MAY INTERACT with Tri-Luma. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Corticosteroids (eg, prednisone) because the risk of their side effects may be increased by Tri-Luma


• Medicines that may increase your risk of sunburn (eg, tetracycline, hydrochlorothiazide). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase your sunburn risk.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tri-Luma may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tri-Luma:

Use Tri-Luma as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Tri-Luma. Talk to your pharmacist if you have questions about this information.


• Tri-Luma is for external use only.


• Apply Tri-Luma at least 30 minutes before bedtime.


• Wash your hands before and after using Tri-Luma.


• Gently wash your face and neck with a mild cleanser. Use your fingers, not a washcloth, to apply the cleanser. Rinse and pat the skin dry. Apply a thin film of medicine to the areas of melasma including about ½ inch of normal appearing skin surrounding each lesion. Rub lightly until the medicine is evenly distributed.


• Do not cover or bandage the treated area unless otherwise directed by your doctor.


• You may apply a moisturizer to the face in the morning after washing.


• If you miss a dose of Tri-Luma, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Tri-Luma.

Important safety information:

• Avoid getting Tri-Luma in your eyes, nose, or mouth. If you get Tri-Luma in your eyes, rinse thoroughly with water.


• Do not use Tri-Luma on open wounds.


• Tri-Luma may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tri-Luma. Use a sunscreen (minimum SPF 30) or wear protective clothing if you must be outside for more than a short time.


• Talk with your doctor before you use any other medicines or products on your skin. Avoid using other topical medication, medicated or abrasive soaps, or other products that have a strong drying effect or a high alcohol content. While you are using Tri-Luma, you may use cosmetics and/or moisturizers.


• Do not apply Tri-Luma to skin that is sunburned. Wait until the burn is fully healed before using Tri-Luma.


• Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Talk with your doctor before you receive any vaccine while you are taking Tri-Luma.


• Hormonal contraceptives (eg, birth control pills) may cause or worsen melasma. If you are using hormonal contraception, talk with your doctor about the use of an alternative form of birth control.


• Do not use Tri-Luma for any condition other than that for which it was prescribed.


• Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Tri-Luma.


• Tri-Luma may cause a gradual blue-black darkening of the skin. Black patients may be at higher risk for this side effect. Contact your doctor immediately if you develop this symptom.


• Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.


• Tri-Luma may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.


• Tri-Luma should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Tri-Luma.


• PREGNANCY and BREAST-FEEDING: It is not known if Tri-Luma may cause harm to the fetus after topical use. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tri-Luma while you are pregnant. It is not known if Tri-Luma is found in breast milk after topical use. If you are or will be breast-feeding while you use Tri-Luma, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Tri-Luma:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; numbness or tingling of the skin; redness, peeling, mild burning, irritation, stinging, dryness, itching, or feeling of warmth at the application site; sensitivity to sunlight.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive hair growth; gradual blue-black darkening of the skin; inflamed hair follicles; inflammation around the mouth; loss of skin color; muscle weakness; severe or persistent burning, redness, swelling, blistering, oozing, crusting, or irritation of the skin; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tri-Luma side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; dizziness; excessive redness, peeling, and discomfort; flushing; headache; stomach pain. Tri-Luma may be harmful if swallowed.

Proper storage of Tri-Luma:

Store Tri-Luma at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly closed container. Store away from heat and light. Do not store in the bathroom. Keep Tri-Luma out of the reach of children and away from pets.

General information:

• If you have any questions about Tri-Luma, please talk with your doctor, pharmacist, or other health care provider.


• Tri-Luma is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tri-Luma. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tri-Luma resources

• Tri-Luma Side Effects (in more detail)
• Tri-Luma Use in Pregnancy & Breastfeeding
• Tri-Luma Drug Interactions
• Tri-Luma Support Group
• 6 Reviews for Tri-Luma - Add your own review/rating

• Tri-Luma Prescribing Information (FDA)


• Tri-Luma Concise Consumer Information (Cerner Multum)

Compare Tri-Luma with other medications

• Melasma

Methotrexate Overdosage Medications

Drugs associated with Methotrexate Overdosage

The following drugs and medications are in some way related to, or used in the treatment of Methotrexate Overdosage. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Drug List:

Fusilev

Gynecort Maximum Strength

Generic Name: hydrocortisone topical (hye droe KOR ti sone)

Brand Names: Ala-Cort, Ala-Scalp HP, Aquanil HC, Beta HC, Caldecort, Cortaid, Cortaid Intensive Therapy, Cortaid Maximum Strength, Cortaid with Aloe, Cortalo with Aloe, Corticaine, Cortizone for Kids, Cortizone-10, Cortizone-10 Intensive Healing Formula, Cortizone-10 Plus, Cortizone-5, Dermarest Dricort, Dermarest Eczema Medicated, Dermarest Plus Anti-Itch, Dermtex HC, Genasone/Aloe, Gly-Cort, Gynecort Maximum Strength, Hycort, Hydrocortisone 1% In Absorbase, Hydrocortisone with Aloe, Hydrocortisone-Aloe, Hytone, Instacort, Itch-X Lotion, Locoid, Locoid Lipocream, Locoid Lotion, Massengill Medicated Soft Cloth, MD Hydrocortisone, Neutrogena T-Scalp, NuCort with Aloe, NuZon, Pandel, Recort Plus, Rederm, Sarnol-HC, Scalacort, Texacort, U-Cort, Westcort

What is Gynecort Maximum Strength (hydrocortisone topical)?

Hydrocortisone is a topical steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Hydrocortisone topical is used to treat inflammation of the skin caused by a number of conditions such as allergic reactions, eczema, or psoriasis.

Hydrocortisone topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Gynecort Maximum Strength (hydrocortisone topical)?

There are many brands and forms of hydrocortisone topical available and not all brands are listed on this leaflet.

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts or for longer than recommended.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with hydrocortisone topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.

Avoid using this medication on your face, near your eyes, or on body areas where you have skin folds or thin skin.

Do not use this medication on a child without a doctor's advice. Children are more sensitive to the effects of hydrocortisone topical.

Hydrocortisone topical will not treat a bacterial, fungal, or viral skin infection.

Contact your doctor if your condition does not improve or if it gets worse after using this medication for several days.

What should I discuss with my healthcare provider before using Gynecort Maximum Strength (hydrocortisone topical)?

Do not use this medication if you are allergic to hydrocortisone.

Hydrocortisone topical will not treat a bacterial, fungal, or viral skin infection.

FDA pregnancy category C. It is not known whether hydrocortisone topical is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether hydrocortisone topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication on a child without a doctor's advice. Children are more sensitive to the effects of hydrocortisone topical.

How should I use Gynecort Maximum Strength (hydrocortisone topical)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger or smaller amounts, or use it for longer than recommended.

Hydrocortisone topical will not treat a bacterial, fungal, or viral skin infection.

Wash your hands before and after each application, unless you are using hydrocortisone topical to treat a hand condition.

Apply a small amount to the affected area and rub it gently into the skin.

Avoid using this medication on your face, near your eyes or mouth, or on body areas where you have skin folds or thin skin.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with hydrocortisone topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions. Contact your doctor if your condition does not improve or if it gets worse after using this medication for several days. It is important to use hydrocortisone topical regularly to get the most benefit. Store hydrocortisone topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine, or if anyone has accidentally swallowed it. An overdose of hydrocortisone topical applied to the skin is not expected to produce life-threatening symptoms.

What should I avoid while using Gynecort Maximum Strength (hydrocortisone topical)?

Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water. Do not use hydrocortisone topical on sunburned, windburned, irritated, or broken skin. Also avoid using this medication in open wounds.

Avoid using skin products that can cause irritation, such as harsh soaps or shampoos or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Gynecort Maximum Strength (hydrocortisone topical) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using hydrocortisone topical and call your doctor at once if you have any of these serious side effects:

• 
  

  blurred vision, or seeing halos around lights;

  
  


• 
  

  uneven heartbeats;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  weight gain, puffiness in your face; or

  
  


• 
  

  feeling tired.

  
  

Less serious side effects may include:

• 
  

  skin redness, burning, itching, or peeling;

  
  


• 
  

  thinning of your skin;

  
  


• 
  

  blistering skin; or

  
  


• 
  

  stretch marks.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Gynecort Maximum Strength (hydrocortisone topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied hydrocortisone. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Gynecort Maximum Strength resources

• Gynecort Maximum Strength Side Effects (in more detail)
• Gynecort Maximum Strength Use in Pregnancy & Breastfeeding
• Gynecort Maximum Strength Drug Interactions
• Gynecort Maximum Strength Support Group
• 0 Reviews for Gynecort Maximum Strength - Add your own review/rating

• Ala-Cort Advanced Consumer (Micromedex) - Includes Dosage Information


• Anusol-HC Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Carmol HC Prescribing Information (FDA)


• Carmol HC MedFacts Consumer Leaflet (Wolters Kluwer)


• Cortizone-10 Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Hydrocortisone Acetate Monograph (AHFS DI)


• Hydrocortisone with Aloe Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Hytone Prescribing Information (FDA)


• Instacort Gel MedFacts Consumer Leaflet (Wolters Kluwer)


• Locoid Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Locoid Lipocream Prescribing Information (FDA)


• Locoid Lotion Prescribing Information (FDA)


• Nutracort Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• Pandel Prescribing Information (FDA)


• Pediaderm HC Lotion MedFacts Consumer Leaflet (Wolters Kluwer)


• ProctoCream-HC Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Proctocort Prescribing Information (FDA)


• Texacort Prescribing Information (FDA)


• U-cort Prescribing Information (FDA)


• Westcort Prescribing Information (FDA)

Compare Gynecort Maximum Strength with other medications

• Anal Itching
• Aphthous Stomatitis, Recurrent
• Atopic Dermatitis
• Dermatitis
• Eczema
• Gingivitis
• Proctitis
• Pruritus
• Psoriasis
• Seborrheic Dermatitis
• Skin Rash
• Ulcerative Colitis, Active

Where can I get more information?

• Your pharmacist can provide more information about hydrocortisone topical.

See also: Gynecort Maximum Strength side effects (in more detail)

Safyral

Generic Name: drospirenone, ethinyl estradiol, and levomefolate (droe SPYE re none, ETH in il ES tra DYE ol, and LEE voe me FOE late )

Brand Names: Beyaz, Safyral

What is drospirenone, ethinyl estradiol, and levomefolate?

Drospirenone and ethinyl estradiol prevent ovulation (the release of an egg from an ovary) and also cause changes in your cervical and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Levomefolate is a type of B vitamin that is normally found in foods. Levomefolate helps prevent a rare birth defect that could occur in a baby if the pregnancy occurs while taking birth control pills or shortly after stopping them.

Drospirenone, ethinyl estradiol, and levomefolate is used as contraception to prevent pregnancy. The Beyaz brand of this medication is also used to treat moderate acne in women who are at least 14 years old and have started having menstrual periods, and who wish to use birth control pills to prevent pregnancy.

Beyaz is also used to treat the symptoms of premenstrual dysphoric disorder (PMDD), such as anxiety, depression, irritability, trouble concentrating, lack of energy, sleep or appetite changes, breast tenderness, joint or muscle pain, headache, and weight gain. Beyaz will not treat symptoms of premenstrual syndrome (PMS).

Drospirenone, ethinyl estradiol, and levomefolate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about drospirenone, ethinyl estradiol, and levomefolate?

Do not use this medication if you are pregnant. Do not use if you have any of the following conditions: a history of stroke or blood clot, history of heart attack, circulation problems (especially if caused by diabetes), a blood-clotting disorder, a heart valve disorder, coronary heart disease, breast or uterine cancer, unusual vaginal bleeding, kidney or liver disease, an adrenal gland disorder, uncontrolled high blood pressure, severe migraines, a history of jaundice caused by pregnancy, or if you are 35 or older and you smoke.

What should I discuss with my healthcare provider before taking drospirenone, ethinyl estradiol, and levomefolate?

Do not use this medication if you are pregnant. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills (or until you stop breast-feeding). Do not use this medication if you have any of the following conditions:

• 
  

  a heart valve disorder, blood-clotting disorder, uncontrolled high blood pressure, coronary heart disease, or severe migraine headaches;

  
  


• 
  

  a history of heart attack, stroke, or blood clot (especially in your leg, lung, or eye);

  
  


• 
  

  problems with your eyes, kidneys, or circulation caused by diabetes;

  
  


• kidney disease or adrenal gland disorder;


• liver disease or liver cancer;


• 
  

  unusual vaginal bleeding;

  
  


• 
  

  any type of breast, uterine, or hormone-dependent cancer;

  
  


• 
  

  a history of jaundice caused by pregnancy; or

  
  


• 
  

  if you are 35 or older and you smoke.

  
  

To make sure you can safely take drospirenone, ethinyl estradiol, and levomefolate, tell your doctor if you have any of these other conditions:

• 
  

  high blood pressure or heart disease;

  
  


• 
  

  high cholesterol or triglycerides;

  
  


• 
  

  high levels of potassium in your blood;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  diabetes;

  
  


• 
  

  seizures or epilepsy; or

  
  


• 
  

  a history of depression.

  
  

FDA pregnancy category X. Do not use this medication if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. The hormones in this medicine can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

How should I take drospirenone, ethinyl estradiol, and levomefolate?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. You will take your first pill on the first day of your period or on the first Sunday after your period begins (follow your doctor's instructions).

Use back-up birth control (condoms or spermicide), for the first 7 days of using this medication.

The 28-day birth control pack contains reminder pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills.

Take one pill with every evening meal or at bedtime, no more than 24 hours apart. When the pills run out, start a new pack the following day. Get your prescription refilled before you run out of pills completely.

You may have breakthrough bleeding. Tell your doctor if this bleeding continues or is very heavy.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medication for a short time (starting 4 weeks before a surgery). Any doctor or surgeon who treats you should know that you are using birth control pills.

Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Missing a pill increases your risk of becoming pregnant.

If you miss one active pill, take two pills on the day that you remember. Then take one pill per day for the rest of the pack.

If you miss two active pills in a row in week 1 or 2, take two pills per day for two days in a row. Then take one pill per day for the rest of the pack. Use back up birth control for at least 7 days.

If you miss two active pills in a row in week 3, or if you miss three pills in a row during any of the first 3 weeks, throw out the rest of the pack and start a new one the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new one that day.

If you miss two or more pills, you may not have a period during the month. If you miss a period for two months in a row, call your doctor because you might be pregnant.

If you miss one of the reminder pills in week four, skip that dose and take the next one as directed.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, or vaginal bleeding.

What should I avoid while taking drospirenone, ethinyl estradiol, and levomefolate?

Do not smoke while using this medication, especially if you are older than 35. Smoking can increase your risk of blood clots, stroke, or heart attack caused by birth control pills.

Drospirenone, ethinyl estradiol, and levomefolate will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.

Drospirenone, ethinyl estradiol, and levomefolate side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have a serious side effect such as:

• 
  

  sudden numbness or weakness, confusion, pain behind the eyes, problems with vision, speech, or balance;

  
  


• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  
  


• 
  

  a change in the pattern or severity of migraine headaches;

  
  


• 
  

  jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  symptoms of depression (sleep problems, weakness, mood changes).

  
  

Less serious side effects may include:

• 
  

  breast pain, tenderness, or swelling;

  
  


• 
  

  mild headache, feeling tired or irritable;

  
  


• 
  

  bloating, stomach pain, mild nausea;

  
  


• 
  

  weight gain, swelling of your hands or feet;

  
  


• 
  

  problems with contact lenses;

  
  


• 
  

  loss of interest in sex; or

  
  


• 
  

  changes in your menstrual periods.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect drospirenone, ethinyl estradiol, and levomefolate?

Some drugs can make birth control pills less effective, which may result in pregnancy. Other drugs may be affected by drospirenone, ethinyl estradiol, and levomefolate. Tell your doctor about all other medicines you use, especially:

• 
  

  bosentan (Tracleer);

  
  


• 
  

  folic acid or potassium supplements;

  
  


• 
  

  heparin;

  
  


• 
  

  St. John's wort;

  
  


• 
  

  antibiotics such as griseofulvin (Fulvicin) or rifampin (Rifadin, Rifater, Rifamate);

  
  


• 
  

  heart or blood pressure medication, including diuretics (water pills);

  
  


• 
  

  HIV or AIDS medications;

  
  


• 
  

  antifungal medicines;

  
  


• 
  

  NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), celecoxib (Celebrex), and others;

  
  


• 
  

  phenobarbital (Solfoton) and other barbiturates; or

  
  


• 
  

  seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), lamotrigine (Lamictal), oxcarbazepine (Trileptal), phenytoin (Dilantin), and others.

  
  

This list is not complete and there are many other drugs that can interact with drospirenone, ethinyl estradiol, and levomefolate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More Safyral resources

• Safyral Side Effects (in more detail)
• Safyral Use in Pregnancy & Breastfeeding
• Safyral Drug Interactions
• Safyral Support Group
• 25 Reviews for Safyral - Add your own review/rating

• Safyral Prescribing Information (FDA)


• Safyral Advanced Consumer (Micromedex) - Includes Dosage Information


• Safyral MedFacts Consumer Leaflet (Wolters Kluwer)


• Safyral Consumer Overview


• Beyaz Prescribing Information (FDA)


• Beyaz MedFacts Consumer Leaflet (Wolters Kluwer)


• Beyaz Consumer Overview

Compare Safyral with other medications

• Birth Control

Where can I get more information?

• Your pharmacist can provide more information about drospirenone, ethinyl estradiol, and levomefolate.

See also: Safyral side effects (in more detail)

Myocet

MYOCET 50mg

powder and pre-admixtures for concentrate for liposomal dispersion for infusion

Doxorubicin HCI

Read all of this leaflet carefully, before you start using this medicine.

• Keep this leaflet. You may need to read it again.


• If you have any further questions, ask your doctor or your hospital pharmacist.


• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.


• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor.

In this leaflet:

• 1. What MYOCET is and what is it used for.


• 2. Before you use MYOCET.


• 3. How to use MYOCET.


• 4. Possible side effects.


• 5. How to store MYOCET.


• 6. Further information

What Myocet Is And What Is It Used For

MYOCET consists of a powder and pre-admixtures for concentrate for liposomal dispersion for infusion and is supplied as a three-vial system: MYOCET doxorubicin HCI, MYOCET liposomes and MYOCET buffer. The active substance is presented as a lyophilised powder for single-use.

Once the content of the vials has been mixed together the resulting liposomal dispersion is orange-red and opaque.

MYOCET is available in cartons containing 2 sets of the three constituents.

MYOCET is a preparation of the anti-tumour agent doxorubicin, which is encased in microscopic fat particles known as liposomes. Doxorubicin belongs to a group of anti-tumour medicines called anthracyclines. It damages the tumour cells.

MYOCET, in combination with cyclophosphamide, is used for the first-line treatment of metastatic breast cancer in women.

Before You Use Myocet

You should tell your doctor if:

• you are allergic to doxorubicin or any of the ingredients contained in MYOCET.


• you are pregnant, or think you may be pregnant, or are breast-feeding.


• you have a history of cardiovascular disease (for example heart attacks, heart failure or long-standing high blood pressure).


• you have problems with your liver.

Do not use MYOCET if:

• you are allergic to doxorubicin or any of the ingredients contained in MYOCET.

Take special care with MYOCET.

Doxorubicin may cause blood disorders and heart problems; therefore careful monitoring will be performed.

Doxorubicin is an irritant and special care should be taken when administering the infusion of MYOCET. If MYOCET leaks from the infusion site into the skin and surrounding tissues, the infusion must be stopped immediately and ice applied to the affected area for 30 minutes. Subsequently, the MYOCET infusion will be started in another vein.

MYOCET may cause infusion-related side effects, such as flushing, fever, chills, headaches and back pain. These can be avoided by increasing the length of time the infusion is given over.

Using MYOCET with food and drink.

There are no known interactions with food and drink.

Pregnancy and breast-feeding

Tell your doctor or pharmacist if you are pregnant, think you may be pregnant or are breast-feeding, before you receive treatment with this medicine. MYOCET can not be used in pregnancy and women receiving MYOCET should not breast-feed. Women of childbearing potential should use an effective contraceptive during and up to 6 months after treatment with MYOCET.

Driving and using machines:

MYOCET has been reported to cause dizziness. If you feel dizzy or are unsure of yourself do not drive or operate machinery.

Taking other medicines:

Please inform your doctor or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed. MYOCET may interact with substances that are known to interact with doxorubicin. Such substances include cyclosporin, phenobarbital, streptozocin, phenytoin, warfarin.

How To Use Myocet

The dose of MYOCET will be calculated according to the surface area of your body. When MYOCET is administered in combination with cyclophosphamide the generally recommended dose is 60-75mg/m². Your doctor will work out exactly how much you need based on your individual circumstances and may choose to lower the dose.

MYOCET is administered by a health care professional as an intravenous infusion, after reconstitution of the individual vials and dilution.

The infusion will be carried out one day every 3 weeks.

The number of infusions will depend on the circumstances of your disease or response to the medicine. Repeated treatment courses with MYOCET are possible. Treatment usually lasts for approximately 3-6 months.

Myocet Side Effects

Like all medicines, MYOCET can have side effects.

The very common side effects are blood disorders, where reduced levels of certain blood cells may cause:

• reduced resistance to infection or fever,


• sore mouth or throat and mouth ulcers,


• increased bruising,


• tiredness, lack of energy, feeling dizzy.

Your doctor will monitor your blood regularly for these effects and will decide if specific treatment is required.

Other very common side effects may include:

• diarrhoea, vomiting and feeling sick,


• hair loss.

Other less common side effects may include:

• shortness of breath and swollen ankles because of heart failure, irregular heart beat, low potassium level in the blood (which may be noticed as weakness and cramps),


• breathing difficulties, cough, chest pains and fainting, coughing blood,


• swelling and reddening and blistering of the skin around the injection site,


• stomach pains from an open sore on the lining of the stomach, also called gastric ulcer and pain and swelling of the food pipe,


• fever and chills (covers pneumonitis, plus breathing difficulties and cough), muscle weakness and aches,


• yellowing of the skin and/or eyes, also called jaundice,


• change in frequency of urination, painful urination and blood in the urine,


• constipation, feeling thirsty and loss of appetite,


• skin problems including itchiness of the skin, tender, swollen areas around hair roots and nail disorder,


• abnormal manner of walking,


• speech difficulties,


• back pain,


• nose bleeds,


• agitation,


• sleepiness or drowsiness but sometimes insomnia.

During the infusion at the hospital, you may have an allergic reaction and notice any of the following:

• breathlessness,


• tightness in the chest and throat,


• fever and chills,


• facial swelling,


• dizziness,


• light-headedness,


• tiredness,


• headache,


• back pain,


• flushing.

If you notice any side effects not mentioned in this leaflet, please inform your doctor or pharmacist.

How To Store Myocet

Keep out of the reach and sight of children.

Store in a refrigerator (2°C - 8°C).

From a microbiological point of view, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2°C - 8°C, unless reconstitution and dilution has taken place in controlled and validated aseptic conditions.

Do not use after the expiry date stated on the label and carton.

Do not use MYOCET if you notice that it shows evidence of discoloration, precipitation or any other particulate matter.

Further Information

What MYOCET contains:

MYOCET 50mg powder and pre-admixtures for concentrate for liposomal dispersion for infusion

Liposomal doxorubicin

• The active substance is doxorubicin HCI, 50mg.


• The other ingredients are lactose (MYOCET doxorubicin HCI vial), egg phosphatidylcholine, cholesterol, citric acid and sodium hydroxide and water for injections (MYOCET liposomes vial), and sodium carbonate and water for injections (MYOCET buffer vial).

Marketing Authorisation Holder and Manufacturer:

The marketing authorisation holder is:

Cephalon Europe

5 Rue Charles Martigny

94700 Maisons Alfort

France

The Manufacturer is:

GP-Pharm

Polígon Industrial Els Vinyets - Els Fogars

Sector 2

Carretera Comarcal C244, km 22

08777 Sant Quintí de Mediona (Barcelona)

Spain

This leaflet was last approved on: 11/2008

1686/1

PR - MYOC601 - GB - 02

Panhematin

Generic Name: hemin (HEE min)

Brand Names: Panhematin

What is Panhematin (hemin)?

Hemin is an enzyme inhibitor that is made from red blood cells. It works by lowering the production of a certain enzyme in the body.

Hemin is used to treat the symptoms of occasional attacks of porphyria related to the menstrual cycle in women. Hemin helps control symptoms such as pain, increased heart rate or blood pressure, and changes in mental status.

Hemin should not be used to treat porphyria cutanea tarda.

Hemin is not a cure for porphyria. It will only control the symptoms of a porphyria episode.

Hemin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Panhematin (hemin)?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Using too much hemin could be harmful to your kidneys. Follow the directions on your prescription label.

You should not use this medication if you are allergic to hemin.

Before using hemin, tell your doctor if you are allergic to latex rubber.

Also tell your doctor if you take birth control pills, hormone replacement therapy, a blood thinner, steroids, or a barbiturate sedative.

Hemin is made from human blood and may contain viruses and other infectious agents that can cause disease. Although donated human blood is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

What should I discuss with my health care provider before using Panhematin (hemin)?

You should not use this medication if you are allergic to hemin.

Before using hemin, tell your doctor if you are allergic to latex rubber.

FDA pregnancy category C. Hemin may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether hemin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Hemin is made from human blood and may contain viruses and other infectious agents that can cause disease. Although donated human blood is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

How should I use Panhematin (hemin)?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Using too much hemin could be harmful to your kidneys. Follow the directions on your prescription label.

Hemin is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject hemin if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

For best results from this medication, start using it at the first sign of a porphyria attack.

Hemin injected through an IV infusion can take 10 or 15 minutes to complete. You may need to use hemin daily for up to 2 weeks depending on how your body responds to the medication.

Hemin powder must be mixed with a liquid (diluent) just before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

After mixing hemin with the diluent, shake the mixture for 2 or 3 full minutes to help the medication dissolve completely.

Give the injection right away after mixing the medication. Do not save it for later use. Throw away any unused mixture after giving your injection.

To be sure this medication is helping your condition, your urine may need to be tested on a regular basis. Do not miss any scheduled appointments.

Store unmixed hemin powder in the refrigerator.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include urinating less than usual or not at all.

What should I avoid while using Panhematin (hemin)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using hemin.

Panhematin (hemin) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using hemin and call your doctor at once if you have a serious side effect such as:

• 
  

  urinating less than usual or not at all;

  
  


• 
  

  swelling, weight gain, feeling short of breath;

  
  


• 
  

  fever;

  
  


• 
  

  easy bruising or bleeding; or

  
  


• 
  

  swelling, pain, or irritation around the IV needle.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Panhematin (hemin)?

Tell your doctor about all other medications you use, especially:

• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  birth control pills or hormone replacement therapy;

  
  


• 
  

  a steroid medication; or

  
  


• 
  

  a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton).

  
  

This list is not complete and there may be other drugs that can interact with hemin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Panhematin resources

• Panhematin Side Effects (in more detail)
• Panhematin Use in Pregnancy & Breastfeeding
• Panhematin Drug Interactions
• Panhematin Support Group
• 0 Reviews for Panhematin - Add your own review/rating

• Panhematin Prescribing Information (FDA)


• Panhematin MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Panhematin with other medications

• Porphyria

Where can I get more information?

• Your doctor or pharmacist can provide more information about hemin.

See also: Panhematin side effects (in more detail)

Poly-Tussin DM Liquid

Pronunciation: klor-fen-EER-a-meen/dex-troe-meth-OR-fan/fen-ill-EF-rin
Generic Name: Chlorpheniramine/Dextromethorphan/Phenylephrine
Brand Name: Examples include Poly-Tussin DM and Ceron-DM

Poly-Tussin DM Liquid is used for:

Relieving sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Poly-Tussin DM Liquid is a decongestant, antihistamine, and cough suppressant combination. It works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking histamine, which helps reduce symptoms, such as watery eyes and sneezing, while the cough suppressant works in the brain to help decrease the cough reflex.

Do NOT use Poly-Tussin DM Liquid if:

• you are allergic to any ingredient in Poly-Tussin DM Liquid


• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems


• you are unable to urinate or are having an asthma attack


• you take sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Poly-Tussin DM Liquid:

Some medical conditions may interact with Poly-Tussin DM Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, plan to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a fast, slow, or irregular heartbeat


• if you have a history of adrenal gland problems (eg, tumor); heart problems; high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma; a blockage of your stomach, intestines, or bladder; ulcers; trouble urinating; an enlarged prostate or other prostate problems; seizures; or an overactive thyroid


• if you have a history of asthma, chronic cough, chronic obstructive pulmonary disease (COPD), or other lung problems (eg, chronic bronchitis, emphysema), or if your cough produces large amounts of mucus

Some MEDICINES MAY INTERACT with Poly-Tussin DM Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), COMT inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Poly-Tussin DM Liquid may be increased


• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Bromocriptine or hydantoins (eg, phenytoin) because side effects may be increased by Poly-Tussin DM Liquid


• Guanadrel, guanethidine, methyldopa, mecamylamine, or reserpine because their effectiveness may be decreased by Poly-Tussin DM Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Poly-Tussin DM Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Poly-Tussin DM Liquid:

Use Poly-Tussin DM Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Poly-Tussin DM Liquid may be taken with or without food.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Poly-Tussin DM Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Poly-Tussin DM Liquid.

Important safety information:

• Poly-Tussin DM Liquid may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Poly-Tussin DM Liquid. Using Poly-Tussin DM Liquid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Do not take diet or appetite control medicines while you are taking Poly-Tussin DM Liquid without checking with your doctor.


• Poly-Tussin DM Liquid contains phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.


• Do NOT exceed the recommended dose or take Poly-Tussin DM Liquid for longer than prescribed without checking with your doctor.


• If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.


• Poly-Tussin DM Liquid may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Poly-Tussin DM Liquid. Use a sunscreen or protective clothing if you must be outside for a prolonged period.


• If you are scheduled for allergy skin testing, do not take Poly-Tussin DM Liquid for several days before the test because it may decrease your response to the skin tests.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Poly-Tussin DM Liquid.


• Use Poly-Tussin DM Liquid with caution in the ELDERLY because they may be more sensitive to its effects.


• Caution is advised when using Poly-Tussin DM Liquid in CHILDREN because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Poly-Tussin DM Liquid, discuss with your doctor the benefits and risks of using Poly-Tussin DM Liquid during pregnancy. It is unknown if Poly-Tussin DM Liquid is excreted in breast milk. Do not breast-feed while taking Poly-Tussin DM Liquid.

Possible side effects of Poly-Tussin DM Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

See also: Poly-Tussin DM side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; severe dizziness, lightheadedness, or headache; severe drowsiness; seizures; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Poly-Tussin DM Liquid:

Store Poly-Tussin DM Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Poly-Tussin DM Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Poly-Tussin DM Liquid, please talk with your doctor, pharmacist, or other health care provider.


• Poly-Tussin DM Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Poly-Tussin DM Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Poly-Tussin DM resources

• Poly-Tussin DM Side Effects (in more detail)
• Poly-Tussin DM Use in Pregnancy & Breastfeeding
• Poly-Tussin DM Drug Interactions
• Poly-Tussin DM Support Group
• 0 Reviews for Poly-Tussin DM - Add your own review/rating

Compare Poly-Tussin DM with other medications

• Cough and Nasal Congestion

Acetaminophen/Phenyltoloxamine Liquid

Pronunciation: ah-seet-ah-MIN-oh-fen/fen-ill-tole-OX-a-meen
Generic Name: Acetaminophen/Phenyltoloxamine
Brand Name: Dologesic

Acetaminophen/Phenyltoloxamine Liquid is used for:

Treating mild to moderate aches and pains associated with headache, muscle and joint soreness, backache, menstrual cramps, colds and flu, sinusitis, toothache, and minor pain from arthritis, and to reduce fever. It may also be used for other conditions as determined by your doctor.

Acetaminophen/Phenyltoloxamine Liquid is an analgesic, antihistamine, and antipyretic combination. It works by blocking substances in the body that cause fever, pain, and inflammation. It also blocks histamine, which causes sneezing and itchy, watery eyes.

Do NOT use Acetaminophen/Phenyltoloxamine Liquid if:

• you are allergic to any ingredient in Acetaminophen/Phenyltoloxamine Liquid


• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Phenyltoloxamine Liquid:

Some medical conditions may interact with Acetaminophen/Phenyltoloxamine Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have bleeding problems, blood vessel problems in the brain, a blockage of the stomach or bowel, a blockage of the bladder, or difficulty urinating


• if you have lung problems (eg, asthma, emphysema, chronic obstructive pulmonary disease [COPD]), an enlarged prostate, glaucoma, kidney problems, or liver problems

Some MEDICINES MAY INTERACT with Acetaminophen/Phenyltoloxamine Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Isoniazid, monoamine oxidase (MAO) inhibitors (eg, phenelzine), or sodium oxybate (GHB) because the risk of side effects may be increased


• Anticoagulants (eg, warfarin) because the risk of side effects, including the risk of bruising or bleeding, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Phenyltoloxamine Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Phenyltoloxamine Liquid:

Use Acetaminophen/Phenyltoloxamine Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Acetaminophen/Phenyltoloxamine Liquid may be taken with or without food.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Acetaminophen/Phenyltoloxamine Liquid and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Phenyltoloxamine Liquid.

Important safety information:

• Acetaminophen/Phenyltoloxamine Liquid may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Acetaminophen/Phenyltoloxamine Liquid. Using Acetaminophen/Phenyltoloxamine Liquid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Acetaminophen/Phenyltoloxamine Liquid contains acetaminophen. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen. If it does or if you are uncertain, contact your doctor or pharmacist.


• Avoid taking medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Acetaminophen/Phenyltoloxamine Liquid. Acetaminophen/Phenyltoloxamine Liquid will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• Do not exceed the recommended dosage or take Acetaminophen/Phenyltoloxamine Liquid for longer than prescribed without checking with your doctor.


• If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Acetaminophen/Phenyltoloxamine Liquid or other pain relievers/fever reducers. Acetaminophen may cause liver damage. Alcohol use combined with Acetaminophen/Phenyltoloxamine Liquid may increase your risk for liver damage.


• If you are taking Acetaminophen/Phenyltoloxamine Liquid for pain or fever and your symptoms do not improve within 10 days or if they become worse, check with your doctor.


• Before you have any medical or dental treatments or surgery, tell the doctor or dentist that you are taking Acetaminophen/Phenyltoloxamine Liquid.


• Caution is advised when using Acetaminophen/Phenyltoloxamine Liquid in CHILDREN because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: It is unknown if Acetaminophen/Phenyltoloxamine Liquid can cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Acetaminophen/Phenyltoloxamine Liquid during pregnancy. Acetaminophen/Phenyltoloxamine Liquid is excreted in breast milk. Do not breast-feed while taking Acetaminophen/Phenyltoloxamine Liquid.

Possible side effects of Acetaminophen/Phenyltoloxamine Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth, nose, or throat; heartburn; nausea; thickening of mucus in the nose and throat; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine or pale stools; decreased urination; severe stomach pain; unusual bruising or bleeding; unusual tiredness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Acetaminophen/Phenyltoloxamine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include abnormal behavior; dark urine; excessive sweating; extreme tiredness; fast or deep breathing; loss of consciousness; ringing in the ears; stomach pain; vomiting.

Proper storage of Acetaminophen/Phenyltoloxamine Liquid:

Store Acetaminophen/Phenyltoloxamine Liquid at room temperature, 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Phenyltoloxamine Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Acetaminophen/Phenyltoloxamine Liquid, please talk with your doctor, pharmacist, or other health care provider.


• Acetaminophen/Phenyltoloxamine Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Acetaminophen/Phenyltoloxamine Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Acetaminophen/Phenyltoloxamine resources

• Acetaminophen/Phenyltoloxamine Side Effects (in more detail)
• Acetaminophen/Phenyltoloxamine Use in Pregnancy & Breastfeeding
• Acetaminophen/Phenyltoloxamine Drug Interactions
• Acetaminophen/Phenyltoloxamine Support Group
• 13 Reviews for Acetaminophen/Phenyltoloxamine - Add your own review/rating

Compare Acetaminophen/Phenyltoloxamine with other medications

• Cold Symptoms
• Headache
• Influenza
• Pain

LoHist-D

Generic Name: chlorpheniramine and pseudoephedrine (klor fen EER a meen and soo doe e FED rin)

Brand Names: AccuHist Drops, Allerest Maximum Strength, Brexin L.A., Colfed-A, D-Amine-SR, Dayquil Allergy, Deconamine, Dicel, Dicel Chewables, Dura-Tap/PD, Durafed, Duratuss DA, Dynahist-ER Pediatric, Genaphed Plus, Histade, Histex, Kronofed-A, Kronofed-A-Jr, LoHist-D, Mintex, Neutrahist Drops, Re2+30, Rescon-Ed, Suclor, SudaHist, Sudal-12 Chewable, Sudal-12 Tannate, Sudogest Cold & Allergy, SudoGest Sinus & Allergy, Tavist-DA, Triaminic Cold and Allergy, Triaminic Softchew Cold and Allergy, Triaminic Softchews Allergy Runny Nose and Congestion

What is LoHist-D (chlorpheniramine and pseudoephedrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine and pseudoephedrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about LoHist-D (chlorpheniramine and pseudoephedrine)?

There are many brands and forms of this medication available and not all brands are listed on this leaflet.

Do not use chlorpheniramine and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to chlorpheniramine or pseudoephedrine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and pseudoephedrine. Older adults may be more likely to have side effects from this medicine. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my healthcare provider before taking LoHist-D (chlorpheniramine and pseudoephedrine)?

Do not use chlorpheniramine and pseudoephedrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to chlorpheniramine or pseudoephedrine, or if you have:

• 
  

  severe or uncontrolled high blood pressure;

  
  


• 
  

  severe coronary artery disease;

  
  


• 
  

  narrow angle glaucoma;

  
  


• 
  

  a stomach ulcer;

  
  


• 
  

  if you are unable to urinate; or

  
  


• 
  

  if you are having an asthma attack.

  
  

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

• kidney disease;


• liver disease;


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  circulation problems;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  overactive thyroid;

  
  


• 
  

  a seizure disorder such as epilepsy;

  
  


• 
  

  asthma, emphysema or chronic bronchitis; or

  
  


• 
  

  urination problems or an enlarged prostate.

  
  

FDA pregnancy category C. It is not known whether chlorpheniramine and pseudoephedrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether chlorpheniramine and pseudoephedrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.

Artificially sweetened liquid cold medicine may contain phenylalanine. If you have phenylketonuria (PKU), check the medication label to see if the product contains phenylalanine.

How should I take LoHist-D (chlorpheniramine and pseudoephedrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

The chewable tablet must be chewed before swallowing.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

If you need surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cold medicine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid while taking LoHist-D (chlorpheniramine and pseudoephedrine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine and pseudoephedrine. Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Chlorpheniramine and pseudoephedrine are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

LoHist-D (chlorpheniramine and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  fast or pounding heartbeats;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, nervousness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness; or

  
  


• 
  

  seizure (black-out or convulsions).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry nose or mouth;

  
  


• 
  

  nausea, stomach pain, constipation, loss of appetite;

  
  


• 
  

  dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  ringing in your ears; or

  
  


• 
  

  feeling restless or excited (especially in children).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.

What other drugs will affect LoHist-D (chlorpheniramine and pseudoephedrine)?

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine.

Tell your doctor about all other medications you use, especially:

• 
  

  mecamylamine (Inversine);

  
  


• 
  

  methyldopa (Aldomet);

  
  


• 
  

  reserpine;

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;

  
  


• 
  

  a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), nortriptyline (Pamelor), and others.

  
  

This list is not complete and other drugs may interact with chlorpheniramine and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More LoHist-D resources

• LoHist-D Use in Pregnancy & Breastfeeding
• LoHist-D Drug Interactions
• LoHist-D Support Group
• 0 Reviews for LoHist-D - Add your own review/rating

• AccuHist Drops Prescribing Information (FDA)


• Biohist LA Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Deconamine MedFacts Consumer Leaflet (Wolters Kluwer)


• Deconamine SR Controlled-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)


• Duotan Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• QDALL 24-Hour Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Compare LoHist-D with other medications

• Hay Fever
• Sinusitis

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine and pseudoephedrine.

Roxane Laboratories,Inc.

Address Roxane Laboratories,Inc., 1809 Wilson Rd. Columbus, OH 43216-6532 Contact Details Phone: (800) 962-8364 Website: http://www.roxane.com/

leuprolide

Generic Name: leuprolide (LOO proe lide)

Brand names: Eligard, Lupron, Lupron Depot, Lupron Depot-Gyn, Lupron Depot-Ped, Viadur

What is leuprolide?

Leuprolide is a man-made form of a hormone that regulates many processes in the body. Leuprolide overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. Leuprolide reduces the amount of testosterone in men or estrogen in women.

Leuprolide is used in men to treat the symptoms of prostate cancer. Leuprolide treats only the symptoms of prostate cancer and does not treat the cancer itself. Use any other medications your doctor has prescribed to best treat your condition.

Leuprolide is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.

Leuprolide is also used to treat precocious (early-onset) puberty in both male and female children.

Leuprolide may also be used for purposes not listed in this medication guide.

What is the most important information I should know about leuprolide?

Leuprolide can harm an unborn baby or cause birth defects. Do not use if you are pregnant. You should not breast-feed while you are using leuprolide. You should not use this medication if you are allergic to leuprolide or similar medications such as buserelin (Suprefact, Suprecor), goserelin (Zoladex), histrelin (Supprelin), or nafarelin (Synarel). You should not use leuprolide if you have abnormal vaginal bleeding that has not been diagnosed by a doctor.

Before using leuprolide, tell your doctor if you have epilepsy, asthma, migraines, heart or kidney disease, a history of depression, osteoporosis, bone cancer affecting your spine, blood in your urine, or if you are unable to urinate.

Tell your doctor if you have a personal or family history of osteoporosis, or if you have any risk factors for bone loss such as smoking, alcohol use, or taking steroid or seizure medications long term. Long-term use of this medication may decrease bone density, possibly leading to osteoporosis.

Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medication to make sure you have received the correct brand and strength prescribed by your doctor.

What should I discuss with my healthcare provider before using leuprolide?

Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medication to make sure you have received the correct brand and strength prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy. You should not use this medication if you are allergic to leuprolide or similar medications such as buserelin (Suprefact, Suprecor), goserelin (Zoladex), histrelin (Supprelin), nafarelin (Synarel), or if you have:

• 
  

  abnormal vaginal bleeding that has not been diagnosed by a doctor; or

  
  


• 
  

  if you are pregnant or breast-feeding.

  
  

Do not breast-feed a baby while using leuprolide.

To make sure you can safely use leuprolide, tell your doctor if you have any of these other conditions:

• 
  

  a personal or family history of osteoporosis;

  
  


• 
  

  risk factors for bone loss such as smoking, alcohol use, or taking steroid or seizure medications long term;

  
  


• 
  

  diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol (especially in men);

  
  


• 
  

  epilepsy;

  
  


• 
  

  asthma;

  
  


• 
  

  migraines;

  
  


• 
  

  kidney disease;

  
  


• 
  

  a history of depression;

  
  


• 
  

  bone cancer affecting your spine;

  
  


• 
  

  blood in your urine; or

  
  


• 
  

  if you are unable to urinate.

  
  

FDA pregnancy category X. This medication can cause birth defects. Do not use leuprolide if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Leuprolide usually causes women to stop ovulating or having menstrual periods. However, you may still be able to get pregnant. Use an effective barrier form of birth control (such as a condom or diaphragm with spermicide gel or inserts). Hormonal forms of contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective in preventing pregnancy while you are using leuprolide.

Because leuprolide is expected to cause your menstrual periods to stop, contact your doctor if your periods continue while you are being treated with this medication.

Long-term use of this medication may decrease bone density, possibly leading to osteoporosis. Talk with your doctor about your possible risk for osteoporosis. You may need to receive a bone scan if you ever need to be re-treated with leuprolide in the future.

How should I use leuprolide?

Leuprolide is injected under the skin or into a muscle. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Leuprolide may be given once every month or once every 3 to 6 months. How often you receive this medication will depend on the condition being treated. Follow your doctor's instructions.

Because different brands or strengths of leuprolide are used to treat different conditions, it is very important that you receive exactly the brand and strength your doctor has prescribed. If you self-inject this medication at home, always check your medication to make sure you have received the correct brand and type prescribed by your doctor.

Your symptoms may become temporarily worse as your hormones adjust when you first start using this medication. For best results, keep using the medication as instructed by your doctor. Your condition should eventually improve with continued use of leuprolide.

To be sure this medication is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with leuprolide. You may still need blood tests for up to 3 months after you stop using leuprolide to check your hormone levels and pituitary gland function. Do not miss any scheduled appointments.

Store Lupron in the original carton at room temperature, away from moisture and heat. Store Eligard in the refrigerator. Do not freeze. You may take the medicine out and allow it to reach room temperature before mixing and injecting your dose. After the dose is mixed, you must use the injection within 30 minutes.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

Women who miss more than one leuprolide dose may have breakthrough bleeding. Children who miss more than one dose may have a return of pubertal symptoms such as breast development, growth in the testicles, or menstrual periods.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include weakness, or irritation where the leuprolide shot was given.

What should I avoid while using leuprolide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Leuprolide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  bone pain, loss of movement in any part of your body;

  
  


• 
  

  swelling, rapid weight gain;

  
  


• 
  

  pain, burning, stinging, bruising, or redness where the medication was injected;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  painful or difficult urination;

  
  


• 
  

  urinating more often than usual;

  
  


• 
  

  high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

  
  


• 
  

  sudden numbness or weakness (especially on one side of the body), problems with speech or balance;

  
  


• 
  

  sudden headache with vision problems, vomiting, confusion, slow heart rate, weak pulse, fainting, or slow breathing; or

  
  


• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

  
  

Rare but serious side effects may include:

• 
  

  pain or unusual sensations in your back;

  
  


• 
  

  numbness, weakness, or tingly feeling in your legs or feet;

  
  


• 
  

  muscle weakness or loss of use; and

  
  


• 
  

  loss of bowel or bladder control.

  
  

Less serious side effects may include:

• 
  

  acne, increased growth of facial hair;

  
  


• 
  

  breakthrough bleeding in a female child during the first 2 months of leuprolide treatment;

  
  


• 
  

  dizziness, weakness, tired feeling;

  
  


• 
  

  hot flashes, night sweats, chills, clammy skin;

  
  


• 
  

  nausea, diarrhea, constipation, stomach pain;

  
  


• 
  

  skin redness, itching, or scaling;

  
  


• 
  

  joint or muscle pain;

  
  


• 
  

  vaginal itching or discharge

  
  


• 
  

  breast swelling or tenderness;

  
  


• 
  

  testicle pain;

  
  


• 
  

  impotence, loss of interest in sex;

  
  


• 
  

  depression, sleep problems (insomnia), memory problems; or

  
  


• 
  

  redness, burning, stinging, or pain where the shot was given.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Leuprolide Dosing Information

Usual Adult Dose for Prostate Cancer:

1 mg injection subcutaneously once a day or
7.5 mg depot IM or depot subcutaneously once a month or
22.5 mg depot IM once every 3 months or
30 mg depot IM once every 4 months or
45 mg subcutaneous injection every 6 months or
65 mg subcutaneous implant once every 12 months

Usual Adult Dose for Endometriosis:

3.75 mg IM once a month for up to 6 months or 11.25 mg depot every 3 months.

Usual Adult Dose for Hirsutism:

3.75 mg IM once a month for up to 6 months or 11.25 mg depot every 3 months.

Usual Adult Dose for Uterine Leiomyomata:

3.75 mg IM once a month for up to 6 months or 11.25 mg depot every 3 months.

What other drugs will affect leuprolide?

There may be other drugs that can interact with leuprolide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More leuprolide resources

• Leuprolide Side Effects (in more detail)
• Leuprolide Use in Pregnancy & Breastfeeding
• Leuprolide Drug Interactions
• Leuprolide Support Group
• 53 Reviews for Leuprolide - Add your own review/rating

• leuprolide Intramuscular, Subcutaneous, Intradermal, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Leuprolide MedFacts Consumer Leaflet (Wolters Kluwer)


• Leuprolide Prescribing Information (FDA)


• Eligard Prescribing Information (FDA)


• Eligard Consumer Overview


• Eligard Kit MedFacts Consumer Leaflet (Wolters Kluwer)


• Leuprolide Acetate Monograph (AHFS DI)


• Lupron Consumer Overview


• Lupron Depot Prescribing Information (FDA)


• Lupron Depot MedFacts Consumer Leaflet (Wolters Kluwer)


• Lupron Depot-PED Kit MedFacts Consumer Leaflet (Wolters Kluwer)


• Lupron Depot-PED Prescribing Information (FDA)


• Viadur Prescribing Information (FDA)


• Viadur Implant MedFacts Consumer Leaflet (Wolters Kluwer)

Compare leuprolide with other medications

• Breast Cancer, Adjuvant
• Endometriosis
• Hirsutism
• Precocious Puberty
• Prostate Cancer
• Uterine Fibroids

Where can I get more information?

• Your pharmacist can provide more information about leuprolide.

See also: leuprolide side effects (in more detail)